Pathophysiological changes occurring during Escherichia coli endotoxin and Pasteurella multocida challenge in piglets: relationship with cough and temperature and predicitive value for intensity of lesions.

The aims of this study were (1) to correlate cough and body temperature (BT) with the severity of bronchopneumonia in pigs, (2) to determine whether these clinical signs can be used to early diagnose bronchopneumonia and (3) to assess the predictive values of cough and BT regarding lung lesions. Bronchopneumonia was induced by administering E. coli endotoxin (LPS) combined with Pasteurella multocida type A (PmA) in the trachea of 13 piglets. Saline-instilled negative controls (n = 8), PmA inoculated (n = 6) and LPS instilled (n = 5) groups were also constituted. Cough and BT were recorded daily while the bronchopneumonia severity was assessed using bronchoalveolar lavage fluid (BALF) cytology, cytokines and measurement of lung lesion volume. Changes in expiratory breathing pattern were also measured (Penh). The combination of LPS and PmA induced a subacute bronchopneumonia characterised by macrophage, neutrophil, and lymphocyte infiltration, changes in Penh and an increase in the mRNA level of IFN-gamma while IL8, IL-18 and TNF-alpha mRNA levels remained unchanged. The daily body weight gain of infected animals was significantly reduced. Cough and BT changes were proportional to the intensity of the lung inflammatory process, functional respiratory changes and to the extent of macroscopic lesions. When comparing the individual values of cough and BT to thresholds defined for both parameters, an early diagnosis of pneumonia was possible. Considering the pooled data of each group, it was possible to define thresholds allowing an early segregation between the groups of diseased and healthy piglets. The daily values of cough and BT were predictive for the volume of lung lesions recorded at the end of the trial. In conclusion, cough and BT appear as potential indicators for the intensity and the evolution of the respiratory disease. They also seem to be good predictors for the magnitude of lung lesions and weight gain recorded at the study endpoint

Expansion of the main auroral oval at Jupiter : evidence for Io’s control over the Jovian magnetosphere

In spring 2007, New Horizons' Jupiter fly-by provided a unique opportunity for the largest observation campaign dedicated to the Jovian aurora ever carried out by the Hubble Space Telescope. UV images of the aurora have been acquired on a quasi-daily basis from mid-February to mid-June 2007. Polar projection of the auroral emissions clearly show a continuous long-term expansion of main oval additionally to day by day variations. The main oval moved so much that the Ganymede footprint, which is usually located equatorward of the main emissions, has even been observed inside of it. Simultaneously, the occurrence rate of large equatorward isolated auroral features increased over the season. These emission patches are generally attributed to injections of depleted flux tubes. On 6th June, one of these features exceptionally moved down to the Io footpath. The Io footprint seemed to disappear while the footprint moved through this patch of emission. This disappearance is a unique case among all the UV images of the aurora acquired during the last 12 years. We suggest that all these changes seen in the Jovian aurora are evidence for a major reconfiguration of the magnetosphere induced by increased volcanic activity on Io. Indeed, New Horizons observed particularly intense activity from the Tvashtar volcano in late February 2007. Moreover, sodium cloud brightening caused by volcanic outbursts have also been seen in late May 2007. According to our interpretation, repeated volcanic outbursts beefed up the plasma torus density and its mass outflow rate. This caused the corotation breakdown boundary to migrate closer to Jupiter. Consequently, the main auroral oval moved equatorward. As heavy flux tubes move outward, sparsely filled ones should be injected into the inner magnetosphere in order to conserve the magnetic flux in this region. This phenomenon could explain the large number of injection signatures observed in May-June 2007. Such a cloud of depleted flux tubes probably disrupted the Io-magnetosphere interaction, leading to an abnormally faint Io footprint

Auroral evidence of Io's control over the magnetosphere of Jupiter

Contrary to the case of the Earth, the main auroral oval on Jupiter is related to the breakdown of plasma corotation in the middle magnetosphere. Even if the root causes for the main auroral emissions are Io's volcanism and Jupiter's fast rotation, changes in the aurora could be attributed either to these internal factors or to fluctuations of the solar wind. Here we show multiple lines of evidence from the aurora for a major internally-controlled magnetospheric reconfiguration that took place in Spring 2007. Hubble Space Telescope far-UV images show that the main oval continuously expanded over a few months, engulfing the Ganymede footprint on its way. Simultaneously, there was an increased occurrence rate of large equatorward isolated auroral features attributed to injection of depleted flux tubes. Furthermore, the unique disappearance of the Io footprint on 6 June appears to be related to the exceptional equatorward migration of such a feature. The contemporary observation of the spectacular Tvashtar volcanic plume by the New-Horizons probe as well as direct measurement of increased Io plasma torus emissions suggest that these dramatic changes were triggered by Io's volcanic activity

Energy-flux relationship in the FUV Jovian aurora deduced from HST-STIS spectral observations

[1] Far ultraviolet spectral observations of the Jovian aurora have been made since 1997 with the Space Telescope Imaging Spectrograph (STIS) on board the Hubble Space Telescope at low spectral resolution. The combination of the spectral resolution with the intensity variation along the STIS slit provides information on the latitudinal variation of the precipitating auroral electron energy flux and the mean electron energy, from which the electron current density at the top of the atmosphere can also be deduced. It is found that the mean electron energies associated with the main oval lie in the range 30 - 200 keV and show a tendency to increase with the precipitating energy flux. The current densities lie in the range similar to 0.04 - 0.4 muA m(-2), consistent with previous estimates, and are also positively correlated with the energy flux. The observed relationship between the auroral time-integrated energy fluxes and the electron energies in the main oval is compatible with that expected from Knight's theory of field-aligned currents. The best agreement between the observed data and the Knight curves is obtained for an electron temperature of T-e = 2.5 keV and a source density N = 0.003 cm(-3), that is within the range of values observed in the equatorial plane during the Voyager flybys. No systematic dependence of the electron energy with magnetic local time is found, but the morning sector around 0800 MLT shows greater variability than other regions of the oval. Analysis of time-tagged data shows that the main oval energy flux usually varies steadily over the several minute intervals of observation and that the mean electron energy usually undergoes correlated variations such that the current density remains relatively constant. It is shown that these overall properties are also consistent with Knight's theory of auroral electron acceleration associated with field-aligned current flow, from which it is inferred that the temporal variations observed are often due to slow changes in the magnetospheric "source'' electron parameters in the presence of near-steady magnetosphere-ionosphere coupling currents. By contrast, time-integrated emissions in the polar region are found to be associated with similar mean electron energies to the main oval but with typically smaller energy fluxes and current densities. Pressure balance arguments are advanced, which indicate that the brighter of these emissions must be associated with an auroral acceleration mechanism perhaps similar to that operative in the main oval, while it remains possible that the weaker emissions could result from precipitation from a quasi-isotropic hot magnetospheric electron source

Bifurcations of the main auroral ring at Saturn: ionospheric signatures of consecutive reconnection events at the magnetopause

peer reviewedThis work reports for the first time on bifurcations of the main auroral ring at Saturn observed with the UVIS instrument onboard Cassini. The observation sequence starts with an intensification on the main oval, close to noon, which is possibly associated with dayside reconnection. Consecutive bifurcations appear with the onset of dayside reconnection, between 11 and 18 magnetic local time, while the area poleward of the main emission expands to lower latitudes. The bifurcations depart with time from the main ring of emission, which is related to the open-closed field line boundary. The augmentation of the area poleward of the main emission following its expansion is balanced by the area occupied by the bifurcations, suggesting that these auroral features represent the amount of newly open flux and could be related to consecutive reconnection events at the flank of the magnetopause. The observations show that the open flux along the sequence increases when bifurcations appear. Magnetopause reconnection can lead to significant augmentation of the open flux within a couple of days and each reconnection event opens ∼10% of the flux contained within the polar cap. Additionally, the observations imply an overall length of the reconnection line of ∼4 hours of local time and suggest that dayside reconnection at Saturn can occur at several positions on the magnetopause consecutively or simultaneously

Titan airglow spectra from Cassini Ultraviolet Imaging Spectrograph (UVIS): EUV analysis

peer reviewedaudience: researcher, professional, studentWe present the first UV airglow observations of Titan's atmosphere by the Ultraviolet Imaging Spectrograph (UVIS) on Cassini. Using one spectral channel in the EUV from 561-1182 Å and one in the FUV from 1115-1913 Å, UVIS observed the disk on 13 December, 2004 at low solar activity. The EUV spectrum consists of three band systems of N[SUB]2[/SUB] (b [SUP]1[/SUP]∏[SUB]u[/SUB], b' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP], c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]), while the FUV spectrum consists of one (a [SUP]1[/SUP]∏[SUB]g[/SUB] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]). Both the EUV and FUV spectra contain many N I and N II multiplets that are produced primarily by photodissociative ionization. Spectral intensities of the N[SUB]2[/SUB] c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](v' = 0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP](v'' = 0-2) progression from 950-1010 Å are resolved for the first time. The UVIS observations reveal that the c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP] (0) vibrational band near 958 Å is weak and undetectable, and that N I multiplets near 953.2 and 964.5 Å are present instead. Magnetospheric particle excitation may be weak or sporadic, since the nightside EUV spectrum on this orbit shows no observable nitrogen emission features and only H Ly-β

A chemical survey of exoplanets with ARIEL

Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planet’s birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25–7.8 μm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10–100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed – using conservative estimates of mission performance and a full model of all significant noise sources in the measurement – using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL – in line with the stated mission objectives – will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio